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!important;'><div class='rendered-post' style='max-width: 672px; margin: 0 auto;'><div class='bg-wt-background text-wt-text-on-background'><div style='padding-top:1.5rem; padding-bottom:1.5rem;'><style> .bh__byline_wrapper { font-size: .875rem; line-height: 1.25rem; vertical-align: middle; justify-content: space-between; display: block; } .bh__byline_social_wrapper { display: flex; margin-top: 0.5rem; align-items: center; } .bh__byline_social_wrapper > * + * { margin-left: 0.5rem; } @media (min-width: 768px) { .bh__byline_wrapper { display: flex; } .bh__byline_social_wrapper { margin-top: 0rem; } } </style><div id='web-header' style='padding-left: 2px; padding-right: 2px; color: var(--wt-text-on-background-color) !important; padding-bottom: 2rem;'><h1 style='font-size: 36px; font-family:'Trebuchet MS','Lucida Grande',Tahoma,sans-serif; line-height: 2.5rem; padding-bottom: 8px; font-weight: 700;'>Issue #3 - The FDA approval 30 years in the making</h1><h2 style='font-size: 20px; font-family:'Helvetica',Arial,sans-serif; line-height: 1.75rem; padding-bottom: 0px; font-weight: 400;'>First-ever stem cell therapy cleared, plus: full-fat cheese and dementia risk, why most quit Ozempic, and the right way to walk.</h2><div class='bh__byline_wrapper'><div><div style='display:flex;'><div style='display:flex; flex-direction:row; justify-content:flex-start;'><div style='display:flex;'></div><div style='display:flex; align-items:center;'><p style='left:24px;position:relative;font-family:'Helvetica',Arial,sans-serif;font-weight:400;font-size:14px;color: var(--wt-text-on-background-color);margin:0px;line-height:20px;'><span class='text-wt-text-on-background' style='opacity:0.75;'> December 24, 2025 </span></p></div></div></div></div><div class='bh__byline_social_wrapper'><a href='https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Frenewal-weekly.beehiiv.com%2Fp%2Fissue-3-the-fda-approval-30-years-in-the-making' target='_blank'><div style='max-width:28px;'><svg 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BlinkMacSystemFont, sans-serif;" cellpadding="0" cellspacing="0"><tbody><tr><td style="text-align: left; width: 50%;">Issue #3</td><td style="text-align: right; width: 50%;">Dec 24, 2025</td></tr></tbody></table><div style="margin-bottom: 16px; border-radius: 8px; overflow: hidden;"><a href="https://www.renewalweekly.com?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer"><img src="https://i.imgur.com/dUcJfmW.jpg" alt="Renewal Weekly" style="width: 100%; display: block;"></a></div><table style="width: 100%; padding: 16px 0; margin-bottom: 16px;" cellpadding="0" cellspacing="0"><tbody><tr><td style="text-align: center; vertical-align: middle;"><span style="font-size: 11px; font-weight: 600; letter-spacing: 1px; color: #6B7280; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; margin-right: 12px;">PRESENTED BY</span><a href="https://bulletproof.fdf2.net/m5bJO7?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="vertical-align: middle;"><img src="https://imgur.com/tnGgqhS.jpg" alt="Partner" style="max-width: 120px; max-height: 60px; display: inline-block; vertical-align: middle;"></a></td></tr></tbody></table><div class="rw-body" style="font-size: 16px; line-height: 1.6; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><strong>Ho ho hope you slept well!</strong> Christmas morning is just one day away, and here's a reason to feel good about all that holiday cooking: researchers <a href="https://clf.jhsph.edu/about-us/news/news-2014/study-suggests-home-cooking-main-ingredient-healthier-diet?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">find</a> that people who cook at home consume around 140 fewer calories per meal than those who eat out. So even if you're going back for seconds, you're still ahead. </div><div style="margin-top: 16px;"><p style="font-size: 16px; font-weight: 600; margin-bottom: 12px; font-family: 'Trebuchet MS', Helvetica, sans-serif;">In today's edition:</p><ul style="list-style: none; padding: 0; margin: 0;"><li style="margin-bottom: 6px; font-size: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"> 🧠Early Alzheimer's blocker </li><li style="margin-bottom: 6px; font-size: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"> 🔬 Largest stem cell safety check completed </li><li style="margin-bottom: 6px; font-size: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"> 🚶 Long walks win </li><li style="margin-bottom: 6px; font-size: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"> 📊 Weight-loss drug dropouts </li></ul></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">THIS WEEK'S BIG STORY</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0; line-height: 1.3; font-family: 'Trebuchet MS', Helvetica, sans-serif;">First FDA Stem Cell Approval </h2><div style="margin: 12px -24px;"><a href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-mesenchymal-stromal-cell-therapy-treat-steroid-refractory-acute-graft-versus-host?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer"><img src="https://imgur.com/9bmIPqA.jpg" alt="" style="width: 100%; display: block;"></a></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0;">Diane Serik | Unsplash</p><div style="font-size: 16px; line-height: 1.6;"><p style="margin: 0 0 8px 0;">The FDA <a href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-mesenchymal-stromal-cell-therapy-treat-steroid-refractory-acute-graft-versus-host?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">approved</a> Ryoncil on December 18—the first mesenchymal stromal cell (MSC) therapy ever cleared for use in the United States. The treatment targets steroid-refractory acute graft-versus-host disease (SR-aGVHD) in children as young as 2 months old, a life-threatening condition that emerges after bone marrow transplants. In a 54-patient trial, <strong>70%</strong> of children with this devastating condition responded to Ryoncil within 28 days, including many with the most severe forms of the disease.</p><p style="margin: 0 0 8px 0;">The approval represents a breakthrough moment for a field that's been working toward this milestone for decades. SR-aGVHD affects roughly 1,500 children annually in the U.S. who undergo bone marrow transplants, with about half failing to respond to standard steroid treatment. Until now, children under 12 had no approved options, leaving families with few alternatives when steroids failed.</p><p style="margin: 0 0 8px 0;"><strong style="font-size: 18px; display: block; margin: 16px 0 8px 0;">Not just a first approval</strong></p><p style="margin: 0 0 8px 0;">Ryoncil uses donor bone marrow-derived stem cells that are manufactured at industrial scale and stored frozen, making them immediately available when needed. The cells work by calming the immune system's overreaction that causes the transplanted cells to attack the patient's organs. What makes this particularly significant is that these aren't the patient's own cells—they're "off-the-shelf" cells from healthy donors that can be used in any patient without rejection.</p><p style="margin: 0 0 8px 0;">The path to approval wasn't easy. Mesoblast, the Australian company behind Ryoncil, had its application rejected multiple times over several years before finally meeting FDA standards. The breakthrough offers hope that other MSC therapies now in development—for heart failure, chronic pain, and inflammatory bowel disease—may follow a clearer regulatory path.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><div style="display: flex; align-items: center; margin-bottom: 4px;"><span style="font-size: 18px;">🧬</span><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0;">THE PIPELINE</p></div><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 20px 0; line-height: 1.3; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Where stem cell science stands this week</h2><div style="padding: 16px 0; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; border-bottom: 1px solid #E5E7EB;"><table cellpadding="0" cellspacing="0" border="0" style="margin-bottom: 8px;"><tbody><tr><td style="font-size: 14px; letter-spacing: 2px; color: #7C3AED; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; padding-right: 12px; vertical-align: middle;">●─●─●─●</td><td style="font-size: 11px; font-weight: 700; color: #7C3AED; text-transform: uppercase; letter-spacing: 0.5px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; vertical-align: middle;">PUBLISHED</td></tr></tbody></table><p style="font-size: 15px; font-weight: 600; margin: 0 0 6px 0; line-height: 1.4; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Stem Cell Signals That Control Inflammatory Cell Death: New Research</p><p style="font-size: 14px; color: #4B5563; margin: 0 0 8px 0; line-height: 1.5; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Pyroptosis is a newly discovered form of inflammatory programmed cell death, which is frequently involved in the occurrence and development of vari...</p><a href="https://pubmed.ncbi.nlm.nih.gov/41425572/?fc=20251204105706&ff=20251222134212&v=2.18.0.post22+67771e2&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="font-size: 13px; color: #7C3AED; text-decoration: none; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Published Dec 04, 2025 →</a></div><div style="padding: 16px 0; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; border-bottom: 1px solid #E5E7EB;"><table cellpadding="0" cellspacing="0" border="0" style="margin-bottom: 8px;"><tbody><tr><td style="font-size: 14px; letter-spacing: 2px; color: #7C3AED; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; padding-right: 12px; vertical-align: middle;">●─●─●─●</td><td style="font-size: 11px; font-weight: 700; color: #7C3AED; text-transform: uppercase; letter-spacing: 0.5px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; vertical-align: middle;">PUBLISHED</td></tr></tbody></table><p style="font-size: 15px; font-weight: 600; margin: 0 0 6px 0; line-height: 1.4; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Stem Cells Survive Space Conditions by Boosting Cell Energy Metabolism</p><p style="font-size: 14px; color: #4B5563; margin: 0 0 8px 0; line-height: 1.5; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Glycolysis supports mesenchymal stem cell (MSC) proliferation and sustains their undifferentiated state by maintaining energy supply and limiting a...</p><a href="https://pubmed.ncbi.nlm.nih.gov/41427031/?fc=20251204105706&ff=20251222134212&v=2.18.0.post22+67771e2&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="font-size: 13px; color: #7C3AED; text-decoration: none; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Published Dec 16, 2025 →</a></div><div style="padding: 16px 0; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; "><table cellpadding="0" cellspacing="0" border="0" style="margin-bottom: 8px;"><tbody><tr><td style="font-size: 14px; letter-spacing: 2px; color: #7C3AED; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; padding-right: 12px; vertical-align: middle;">●─●─●─●</td><td style="font-size: 11px; font-weight: 700; color: #7C3AED; text-transform: uppercase; letter-spacing: 0.5px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; vertical-align: middle;">PUBLISHED</td></tr></tbody></table><p style="font-size: 15px; font-weight: 600; margin: 0 0 6px 0; line-height: 1.4; font-family: 'Trebuchet MS', Helvetica, sans-serif;">How Stem Cell Messengers Could Help Treat Heart Diseases</p><p style="font-size: 14px; color: #4B5563; margin: 0 0 8px 0; line-height: 1.5; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">As cardiovascular disease (CVD) is the leading cause of death worldwide, its prevention and treatment is urgent and new therapeutic targets are urg...</p><a href="https://pubmed.ncbi.nlm.nih.gov/41426560/?fc=20251204105706&ff=20251222134212&v=2.18.0.post22+67771e2&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="font-size: 13px; color: #7C3AED; text-decoration: none; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Published Dec 04, 2025 →</a></div></div><div style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">RESEARCH ROUNDUP</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 4px 0; line-height: 1.3;">The largest stem cell safety check—ever</h2><div style="margin: 12px -24px;"><img src="https://imgur.com/ief0bPc.jpg" alt="IPS Stem Cells" style="width: 100%; display: block;"></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0;">Dec 23, 2025 | medicalxpress</p><div style="font-size: 16px; line-height: 1.6;"><p style="margin: 0 0 8px 0;">Scientists counted every pluripotent stem cell trial on the planet and <a href="https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00445-4?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">found</a> something remarkable. After nearly three decades of research, more than <strong>1,200</strong> patients have now received these lab-grown treatments across 116 clinical trials worldwide. That's over 100 billion cells delivered to humans—with zero tumor formation reported.</p><p style="margin: 0 0 8px 0;">The comprehensive analysis published this month in Cell Stem Cell tracked every approved trial of human pluripotent stem cells, those master cells that can transform into any tissue type. Most trials target eye diseases, brain conditions, and cancer, with the majority still in early safety phases.</p><p style="margin: 0 0 8px 0;"><strong>Safety first, scale second</strong></p><p style="margin: 0 0 8px 0;">Despite longstanding fears about these powerful cells potentially forming tumors, the massive patient database shows no pattern of dangerous growths. The treatments span everything from Parkinson's disease to macular degeneration, with some showing meaningful improvements in small studies.</p><p style="margin: 0 0 8px 0;">This represents the largest safety dataset for any emerging cell therapy class—and suggests the field may finally be ready to move beyond cautious first steps toward larger efficacy trials.</p></div></div><div style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px 24px 12px 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">PRESENTED BY BULLETPROOF</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">A holiday morning worth protecting</h2><div style="margin: 0 -24px 16px -24px;"><a href="https://bulletproof.fdf2.net/m5bJO7?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored"><img src="https://imgur.com/XRbZEjf.jpg" alt="Bulletproof Coffee and Collagen Peptides" style="width: 100%; display: block;"></a></div><div style="font-size: 16px; line-height: 1.6;"><p style="margin: 0 0 12px 0;">The holiday season brings enough chaos. Your morning coffee shouldn't add to it. Bulletproof <a href="https://bulletproof.fdf2.net/m5bJO7?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px;">screens</a> for <strong>270+ toxins</strong>—mold, heavy metals, pesticides—so you're starting clean when everything else feels indulgent.</p><p style="margin: 0 0 12px 0;">Their seasonal Cinnamon Vanilla coffee and Peppermint Mocha creamer make it feel festive without the sugar crash. Add a scoop of Collagen Peptides (<strong>20g protein</strong>, grass-fed sourced) and you've got something that actually supports your joints and energy through the long days ahead.</p><p style="margin: 0 0 12px 0;">No seed oils, no junk ingredients. Just a better morning ritual while everyone else reaches for their third holiday cookie.</p></div><a href="https://bulletproof.fdf2.net/m5bJO7?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="display: inline-block; margin-top: 8px; color: #1F2937; text-decoration: none; border-bottom: 2px solid #8B5CF6; font-weight: 600; font-size: 16px;">Shop the Holiday Collection →</a></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">DIET</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0; line-height: 1.3; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Full-fat cheese linked to lower dementia risk</h2><div style="margin: 12px -24px;"><a href="https://www.neurology.org/doi/10.1212/WNL.0000000000214343?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer"><img src="https://imgur.com/NvHAguC.jpg" alt=" parmigiano reggiano" style="width: 100%; display: block;"></a></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0;">Dec 23, 2025 | Antonio Calanni </p><div style="font-size: 16px; line-height: 1.6;"><p style="margin: 0 0 8px 0;">Swedish researchers tracking nearly 28,000 adults for 25 years have <a href="https://www.neurology.org/doi/10.1212/WNL.0000000000214343?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">found</a> that people who regularly ate full-fat cheese and cream developed dementia less often than those who ate little or none. Participants consuming 50 grams or more of high-fat cheese daily—about two slices of cheddar—had a <strong>13%</strong> lower risk of dementia compared to those eating less than 15 grams. Low-fat dairy showed no such association.</p><p style="margin: 0 0 8px 0;">The study, published in Neurology, tracked participants from the Malmö Diet and Cancer cohort who were an average age of 58 at baseline. Over the follow-up period, 3,208 people developed dementia. Those who consumed at least 20 grams of high-fat cream daily—roughly 1.4 tablespoons—showed a 16% lower risk. For vascular dementia specifically, high-fat cheese was linked to a <strong>29%</strong> reduction in risk.</p><p style="margin: 0 0 8px 0;"><strong style="font-size: 18px; display: block; margin: 16px 0 8px 0;">Not all dairy is equal</strong></p><p style="margin: 0 0 8px 0;">The findings didn't extend across all dairy products. Low-fat cheese, low-fat cream, milk, butter, and fermented milk products like yogurt showed no association with dementia risk. One exception: high butter intake (40+ grams daily) was actually linked to increased Alzheimer's risk.</p><p style="margin: 0 0 8px 0;">Genetics also played a role. The protective association between high-fat cheese and Alzheimer's disease appeared only in people who don't carry the APOE ε4 gene variant—a known genetic risk factor for the disease. For carriers, no benefit was observed.</p><p style="margin: 0 0 8px 0;"><strong style="font-size: 18px; display: block; margin: 16px 0 8px 0;">Before you stock up</strong></p><p style="margin: 0 0 8px 0;">This is an observational study showing association, not causation. The research team captured dietary habits only at the study's start in the early 1990s, and all participants lived in Sweden—where hard, fermented cheeses like cheddar and Gouda dominate, often eaten uncooked. American cheese consumption patterns differ significantly, with more processed varieties and heated applications.</p><p style="margin: 0 0 8px 0;">"Our study found that some high-fat dairy products may actually lower the risk of dementia, challenging some long-held assumptions about fat and brain health," said lead author Emily Sonestedt of Lund University. "More research is needed to confirm our results."</p></div></div><div style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">On our radar</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0;">Health breakthroughs worth watching</h2><div style="margin: 12px -24px;"><img src="https://imgur.com/SrTBVjG.jpg" alt="Vision Loss Breakthrough" style="width: 100%; display: block;"></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0;">Dec 23, 2025 | Original image</p><div style="padding-bottom: 24px; margin-bottom: 24px; border-bottom: 1px solid #E5E7EB;"><p style="font-size: 16px; font-weight: 700; line-height: 1.4; margin: 0 0 8px 0;">Vision loss breakthrough</p><p style="font-size: 16px; line-height: 1.6; margin: 0;">Stem cell trials for vision loss are showing renewed hope as researchers work to restore sight in patients with macular degeneration. A leading professor <a href="https://ipscell.com/2025/12/weekly-reads-stem-cells-for-vision-loss-hope-gene-therapy-trial-death-nfl-doc-on-clinics/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">highlighted</a> the promising trial data this week. The approach could offer new options for millions facing age-related blindness.</p></div><div style="padding-bottom: 24px; margin-bottom: 24px; border-bottom: 1px solid #E5E7EB;"><p style="font-size: 16px; font-weight: 700; line-height: 1.4; margin: 0 0 8px 0;">Alzheimer's drug comeback</p><p style="font-size: 16px; line-height: 1.6; margin: 0;">Anavex is pushing for regulators to take another look at their experimental Alzheimer's treatment after earlier setbacks. The company <a href="https://longevity.technology/news/anavex-pushes-for-alzheimers-drug-re-evaluation/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">believes</a> their drug could work for early-stage patients despite previous trial concerns. A favorable re-evaluation could reshape treatment options for millions at risk.</p></div><div style="padding-bottom: px; margin-bottom: 24px; "><p style="font-size: 16px; font-weight: 700; line-height: 1.4; margin: 0 0 8px 0;">Plant beats arthritis</p><p style="font-size: 16px; line-height: 1.6; margin: 0;">Joseph's Coat, a Brazilian folk medicine plant, significantly reduced joint inflammation and swelling in new lab research. Scientists <a href="https://www.sciencedaily.com/releases/2025/12/251221043237.htm?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">confirmed</a> the extract showed strong anti-inflammatory effects with a promising safety profile. The discovery could lead to new plant-based treatments for millions with arthritis.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">HEALTHY HABITS</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0; line-height: 1.3; font-family: 'Trebuchet MS', Helvetica, sans-serif;">How you walk might matter more than how much you walk.</h2><div style="margin: 12px -24px;"><img src="https://imgur.com/xZNBFf8.jpg" alt="snowy forest" style="width: 100%; display: block;"></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0;">Dec 23, 2025 | Original image</p><div style="font-size: 16px; line-height: 1.4;"><p style="margin: 0 0 4px 0;">A massive UK study tracking over <strong>33,000</strong> low-activity adults <a href="https://www.sciencedaily.com/releases/2025/12/251221043233.htm?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">found</a> that people who grouped their daily steps into longer, uninterrupted walks had dramatically lower risks of early death and heart disease compared to those taking short, scattered bursts throughout the day.</p><p style="margin: 0 0 4px 0;"><strong style="font-size: 18px; display: block; margin: 16px 0 8px 0;">Pack your steps together</strong></p><p style="margin: 0 0 4px 0;">The research suggests aiming for walks of at least 10-15 minutes without stopping. Even if you're hitting the same total daily step count, consolidating those steps into fewer, longer sessions appears to deliver superior health benefits.</p><p style="margin: 0 0 4px 0;">• Take one 20-minute walk instead of four 5-minute trips</p><p style="margin: 0 0 4px 0;">• Use lunch breaks for sustained walking rather than quick bathroom runs</p><p style="margin: 0 0 4px 0;">• Walk to complete errands in one longer loop rather than multiple short trips</p><p style="margin: 0 0 4px 0;">• Consider walking meetings that last 15+ minutes</p><p style="margin: 0 0 4px 0;"><strong style="font-size: 18px; display: block; margin: 16px 0 8px 0;">Ditch the step obsession</strong></p><p style="margin: 0 0 4px 0;">• Constantly checking your phone during walks — it breaks the sustained movement pattern</p><p style="margin: 0 0 4px 0;">• Short walks to the mailbox or kitchen — they don't provide the same cardiovascular benefits</p><p style="margin: 0 0 4px 0;">Your heart and longevity markers respond better to sustained, uninterrupted movement than fragmented activity bursts.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px 24px 12px 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">PRESENTED BY Viome</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 6px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Your gut holds answers your doctor can't see.</h2><div style="margin: 0 -24px 16px -24px;"><a href="https://viomehq.sjv.io/c/3937227/1386011/13051?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored"><img src="https://i.imgur.com/Cvz4M4c.jpg" alt="" style="width: 100%; display: block;"></a></div><div style="font-size: 16px; line-height: 1.6;"><p style="margin: 0 0 12px 0;">Most health tests tell you what's wrong after symptoms appear. <a href="https://viomehq.sjv.io/c/3937227/1386011/13051?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">Viome's Full Body Intelligence Test</a> takes a different approach—analyzing your gut microbiome, cellular health, and biological age to reveal what's happening inside before problems start.</p><p style="margin: 0 0 12px 0;">Using advanced AI and RNA sequencing, Viome identifies the precise foods, supplements, and lifestyle changes your unique biology needs. No generic advice. Just personalized recommendations based on over 30 health insights.</p><p style="margin: 0 0 12px 0;">More than 500,000 people have already used Viome to optimize their health from the inside out. The test is simple: a quick at-home collection, lab analysis, and a personalized action plan delivered to your phone.</p><p style="margin: 0 0 12px 0;"><a href="https://viomehq.sjv.io/c/3937227/1386011/13051?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">Take the quiz</a> to see if Viome is right for you—and get started on understanding your body at the cellular level.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">WORTH KNOWING</p><h2 style="font-size: 22px; font-weight: 700; margin: 0 0 16px 0; line-height: 1.3; font-family: 'Trebuchet MS', Helvetica, sans-serif;">This week, keep these on your radar</h2><div style="background: #F9FAFB; border-radius: 8px; padding: 16px; margin-bottom: 12px;"><p style="font-weight: 600; margin: 0 0 10px 0;">Holiday Heart Syndrome <span style="font-size: 12px; background: #EDE9FE; color: #7C3AED; padding: 2px 8px; border-radius: 4px; margin-left: 8px;">December</span></p><p style="font-size: 16px; line-height: 1.6; margin: 0;">ER visits for atrial fibrillation spike 15-20% between Christmas and New Year's. The combination of alcohol, rich foods, sleep disruption, and stress can trigger irregular heartbeats—even in people with no prior heart issues. If you feel your heart racing or fluttering after holiday festivities, don't brush it off. Stay hydrated, moderate alcohol intake, and know that most episodes resolve on their own within 24 hours.</p></div><div style="background: #F9FAFB; border-radius: 8px; padding: 16px; margin-bottom: 12px;"><p style="font-weight: 600; margin: 0 0 10px 0;">Brain Aging Protection Tips </p><p style="font-size: 16px; line-height: 1.6; margin: 0;">Research shows <a href="https://medicalxpress.com/news/2025-12-brain-aging-cells-aid-epilepsy.html?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">clearing aging brain cells</a> could help prevent seizures and cognitive decline: - Get 7-9 hours of quality sleep to support natural brain cleanup - Exercise regularly to promote cellular renewal - Eat antioxidant-rich foods like berries and leafy greens</p></div><div style="background: #F9FAFB; border-radius: 8px; padding: 16px; margin-bottom: 12px;"><p style="font-weight: 600; margin: 0 0 10px 0;">Brain Health Monitoring Advances </p><p style="font-size: 16px; line-height: 1.6; margin: 0;">A startup just <a href="https://longevity.technology/news/neurable-lands-35m-to-advance-brain-health-wearables/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">raised $35 million</a> to develop EEG-powered headphones that monitor cognitive health like a fitness tracker monitors heart rate. While still in development, this represents the future of accessible brain health monitoring—making it as routine as checking your pulse.</p></div><div style="background: #F9FAFB; border-radius: 8px; padding: 16px; margin-bottom: 12px;"><p style="font-weight: 600; margin: 0 0 10px 0;">Post-Stroke Recovery Focus </p><p style="font-size: 16px; line-height: 1.6; margin: 0;">Women <a href="https://www.everydayhealth.com/neurological-disorders/after-stroke-women-struggle-with-daily-tasks-longer-than-men/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">take longer than men</a> to regain daily living skills after stroke. If you're supporting someone's recovery, focus on basic activities like bathing, cooking, and housework—and expect the timeline to vary by individual, not gender assumptions.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; text-align: center; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 14px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 4px 0;">STAT OF THE WEEK</p><p style="font-size: 48px; font-weight: 800; color: #7C3AED; margin: 4px 0 12px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">54%</p><p style="font-size: 18px; font-style: italic; color: #4B5563; margin: 0 0 12px 0;"><em>of Americans quit GLP-1 medications within the first year</em></p><div style="margin: 12px -24px;"><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11786232/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer"><img src="https://imgur.com/1AAcpHV.jpg" alt="54% progress bar" style="width: 100%; display: block;"></a></div><p style="font-size: 11px; color: #6B7280; font-style: italic; margin: 4px 0 12px 0; text-align: left;">Dec 23 | Original image</p><div style="font-size: 16px; line-height: 1.6; text-align: left;"><p style="margin: 0 0 16px 0;">A study of <strong>125,474</strong> patients tracking GLP-1 medications like Ozempic and Wegovy <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11786232/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">found</a> that more than half stopped treatment within a year, and the numbers get worse from there. By two years, <strong>72%</strong> had quit entirely.</p><p style="margin: 0 0 16px 0;">Adults 65 and older were 20-30% more likely to discontinue than younger patients. Those without diabetes fared worst: nearly 65% stopped within the first year, compared to 47% of diabetics, likely because Medicare doesn't cover weight-loss prescriptions.</p><p style="margin: 0 0 16px 0;">The culprits: cost, insurance gaps, and gastrointestinal side effects. Patients experiencing moderate to severe nausea or digestive issues were 38% more likely to quit. Meanwhile, every 1% of body weight lost made patients 3% less likely to stop suggesting those seeing results stick with it.</p><p style="margin: 0 0 16px 0;">These drugs work, but they require long-term commitment. If you're considering GLP-1s, plan for both the financial reality and the adjustment period your body will need.</p></div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">THE PULSE</p><h3 style="font-size: 18px; font-weight: 700; margin: 0 0 20px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Quick hits from the world of health innovation</h3><ul style="list-style: none; padding: 0; margin: 0;"><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">Scientists targeting brain inflammation in Alzheimer's patients <a href="https://www.nature.com/articles/s43587-025-01028-4?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">found</a> a specific receptor reduces amyloid plaques.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">Brain cells in aging adults lose protective protein that <a href="https://www.nature.com/articles/s41514-025-00296-z?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">increases</a> Parkinson's disease risk through chronic inflammation.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">Lab-grown insulin cells function better when researchers <a href="https://www.nature.com/articles/s41467-025-67635-2?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">restored</a> a key enzyme for diabetes treatment.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">3D-printed scaffolds help stem cells grow into muscle tissue <a href="https://www.nature.com/articles/s41598-025-31586-x?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">showing</a> potential for regenerating damaged muscles.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">New peptide gel delivers anti-aging compounds through skin <a href="https://pubmed.ncbi.nlm.nih.gov/41421628/?fc=20251128131039&ff=20251222095936&v=2.18.0.post22+67771e2&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">providing</a> sustained cosmetic benefits.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">Cancer researchers identify protein that helps tumors resist chemotherapy <a href="https://pubmed.ncbi.nlm.nih.gov/41423446/?fc=20251128130949&ff=20251222144458&v=2.18.0.post22+67771e2&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">targeting</a> colorectal cancer stem cells.</li><li style="font-size: 16px; line-height: 1.6; padding: 8px 0;">Republican lawmakers pressure RFK Jr. to allow access <a href="https://ipscell.com/2025/12/gop-lawmakers-ask-rfk-jr-to-make-fda-unleash-risky-peptides-like-bpc-157/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="text-decoration: none; color: #1F2937; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">requesting</a> FDA approval for experimental healing peptides.</li></ul></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">RECS</p><div style="margin: 12px -24px;"><img src="https://i.imgur.com/o5gsn9q.jpg" alt="" style="width: 100%; display: block;"></div><p style="margin: 8px 0; font-size: 16px; line-height: 1.6;"><strong>Read:</strong><a href="https://amzn.to/45aoAWk?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="color: #1F2937; text-decoration: none; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;"> Brain Energy</a> by Christopher Palmer links metabolism to mental health</p><p style="margin: 8px 0; font-size: 16px; line-height: 1.6;"><strong>Watch:</strong> Sara Lazar on <a href="https://www.youtube.com/watch?v=m8rRzTtP7Tc&utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="color: #1F2937; text-decoration: none; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;">how meditation can reshape our brains</a> (8 min)</p><p style="margin: 8px 0; font-size: 16px; line-height: 1.6;"><strong>Try:</strong><a href="https://me.sjv.io/WybkoZ?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener sponsored" style="color: #1F2937; text-decoration: none; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;"> Me+ routine planner</a> a simple tool for building morning routines and tracking your mood, habits, and self-care progress daily.</p><p style="margin: 8px 0; font-size: 16px; line-height: 1.6;"><strong>Listen:</strong><a href="https://theproof.com/podcast/?utm_source=renewal-weekly.beehiiv.com&utm_medium=referral&utm_campaign=issue-3-the-fda-approval-30-years-in-the-making" rel="noopener noreferrer" style="color: #1F2937; text-decoration: none; border-bottom: 2px solid #8B5CF6; padding-bottom: 1px; font-style: normal;"> The Proof</a> with Simon Hill covers brain nutrition</p><p style="font-size: 12px; color: #6B7280; margin-top: 16px; padding-top: 12px; border-top: 1px solid #E5E7EB;"> *these are suggestions from our editorial team; these are not sponsorships or affiliate links </p></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">PLAY</p><div style="margin: 12px -24px;"><img src="https://i.imgur.com/n1K8qvq.jpg" alt="" style="width: 100%; display: block;"></div><p style="color: #4B5563; font-size: 16px; line-height: 1.6; margin-bottom: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Ready to test your health smarts? This 3-question quiz will challenge what you know about staying vibrant and healthy as you age.</p><div style="background: #F9FAFB; border-radius: 8px; padding: 12px 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif; line-height: 1.6; font-size: 16px;"> 1. Which type of exercise has been shown to most effectively slow cellular aging?<br>A) Long-distance running<br>B) High-intensity interval training (HIIT)<br>C) Weightlifting<br>D) Yoga<br><br>2. How many minutes of moderate exercise per week do experts recommend for optimal health benefits?<br>A) 75 minutes<br>B) 150 minutes<br>C) 225 minutes<br>D) 300 minutes<br><br>3. Which nutrient is most critical for maintaining muscle mass after age 50?<br>A) Vitamin D<br>B) Protein<br>C) Calcium<br>D) Magnesium </div></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #FFFFFF; overflow: visible; text-align: center; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 2px 0;">SHARE RENEWAL WEEKLY</p><div style="margin: 12px -24px;"><img src="https://i.imgur.com/kx7sCRJ.jpg" alt="" style="width: 100%; display: block;"></div><p style="font-size: 16px; line-height: 1.6; margin-bottom: 16px; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;">Share Renewal Weekly with someone who wants to stay ahead of the science. <strong>Refer 3 friends and get our free Healthy Diet Guide PDF</strong>, a science-backed roadmap to eating well.</p><p style="margin-bottom: 16px;">Your referral count: <strong>0</strong></p><a href="https://renewal-weekly.beehiiv.com/subscribe?ref=PLACEHOLDER" style="display: inline-block; padding: 12px 32px; background: #7C3AED; color: white; border-radius: 8px; text-decoration: none; font-weight: 600;">Share Now</a><p style="font-size: 12px; color: #6B7280; margin-top: 12px; margin-bottom: 0; word-break: break-all;">https://renewal-weekly.beehiiv.com/subscribe?ref=PLACEHOLDER</p></div><div class="rw-section" style="border: 1px solid #E5E7EB; border-radius: 12px; padding: 24px; margin-bottom: 16px; background: #F9FAFB; overflow: visible; font-family: Helvetica, -apple-system, BlinkMacSystemFont, sans-serif;"><div style="text-align: center; margin-bottom: 20px; padding-bottom: 20px; border-bottom: 1px solid #E5E7EB;"><p style="color: #7C3AED; font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.5px; margin: 0 0 8px 0;">ONE QUICK QUESTION</p><p style="font-size: 18px; font-weight: 600; margin: 0 0 8px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">What's one health habit you're trying to build this month?</p><p style="font-size: 14px; margin: 0 0 4px 0;">Hit reply and let us know—we read every response.</p><p style="font-size: 12px; color: #6B7280; font-style: italic; margin: 0;">(Replies also help our emails land in your inbox instead of spam. Win-win.)</p></div><table width="100%" cellpadding="0" cellspacing="0" border="0"><tbody><tr><td width="48%" style="vertical-align: top; padding-right: 12px;"><p style="font-weight: 600; margin: 0 0 8px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">ANSWER</p><p style="font-size: 14px; color: #4B5563; margin: 0;">1. B) High-intensity interval training (HIIT) - Studies show HIIT can dramatically improve mitochondrial function and slow cellular aging more effectively than steady-state cardio. 2. B) 150 minutes - The CDC recommends 150 minutes of moderate activity or 75 minutes of vigorous activity weekly for optimal health benefits. 3. B) Protein - Maintaining adequate protein intake becomes crucial after 50 to prevent muscle loss and support metabolic health, with experts recommending 1-1.2 grams per kilogram of body weight daily.</p></td><td width="4%" style="vertical-align: top;"></td><td width="48%" style="vertical-align: top; padding-left: 12px; border-left: 1px solid #E5E7EB;"><p style="font-weight: 600; margin: 0 0 8px 0; font-family: 'Trebuchet MS', Helvetica, sans-serif;">Word of the Day</p><p style="font-size: 14px; color: #4B5563; margin: 0;"><strong>Neuroplasticity</strong>: Your brain's superpower to rewire, reorganize, and create new neural connections throughout life - essentially, how your brain adapts, learns, and potentially repairs itself after damage or disease</p></td></tr></tbody></table></div></div><style> p span[style*="font-size"] { line-height: 1.6; } </style><div style="padding-bottom:2px;padding-left:2px;padding-right:2px;padding-top:2px;"><p style="color:#000000;color:var(--wt-text-on-background-color) !important;font-family:'Helvetica',Arial,sans-serif;font-size:16px;line-height:1.7;text-align:left;"></p></div></div></div></div></div></body></html>
